Correlation between serum interleukin-6 with glomerular filtration rate in systemic lupus erythematosus
Keywords:Interleukin-6, Glomerular filtration rate, Systemic lupus erythematosus
Background: Systemic lupus erythematosus (SLE) is characterized by remarkable heterogeneity in clinical manifestations with underlying autoimmune mechanisms. The pleiotropic cytokine interleukin-6 (IL-6) is known to be involved in SLE immunopathogenesis and significantly related to disease activity as well as its complications. Additionally, IL-6 has been demonstrated to underlie important roles in lupus nephritis.
Objective: To determine the correlation between Interleukin 6 (IL-6) Serum and Glomelular Filtration Rate (GFR) in SLE.
Methods: In this study we investigated the correlation of serum IL-6 with glomerular filtration rate (GFR) to assess kidney damage in 67 premenopausal patients aged between 17-50 years with inactive SLE. The study variables including age, duration of illness, cumulative corticosteroid dose, MEX-SLEDAI score, serum creatinine, and GFR were obtained through interview and medical record review; whilst serum level of IL-6 was measured using ELISA.
Results: Median level of IL-6 was found to be 2.71 (0.332-10.000) pg/ml. Pearson correlation test showed significant correlation between serum IL-6 and GFR (r = 0.288, P = 0.018).
Conclusion: This study result shows that there was positive correlation observed between serum IL-6 and GFR in inactive SLE.
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