The addition of Curcuma Xanthorriza to Vitamin D3 supplementation did not affect fatigue and cytokines in lupus patients with hypovitaminosis D

Cesarius Singgih Wahono; Irene Saveria; Handono Kalim; Kusworini Handono

doi:10.36216/jpd.v3i2.98

Authors

Cesarius Singgih Wahono Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia
Irene Saveria Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia
Handono Kalim Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia
Kusworini Handono Department of Clinical Pathology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia

DOI:

https://doi.org/10.36216/jpd.v3i2.98

Keywords:

Fatigue, Hypovitaminosis D, VDR, Curcuma xanthorriza

Abstract

Background: Seventy percent of Lupus patients in Indonesia have hypovitaminosis D. Curcumin is a novel VDR ligand and has synergic effects with vitamin D.

Objective: This study aimed to determine the effect of Curcuma xanthorriza addition to vitamin D₃ supplementation on fatigue, serum IL-6, TGF- ?1, and to study the correlation between fatigue, serum IL-6 and TGF-?1 in lupus patients with hypovitaminosis D.

Methods: This was a double blind randomized controlled trial involving 40 SLE patients with hypovitaminosis D (vitamin D<30 ng/ml). The first group consisted of 20 patients who received Cholecalciferol 1200 IU/day and placebo, and the other group received Cholecalciferol 1200 IU/day and Curcuma xanthorriza 60 mg/day. The subjects were followed up at the end of 3 months. Fatigue were measured by Fatigue Severity Scale (FSS) and Visual Analogue Scale-Fatigue (VAS-F). Vitamin D, serum IL-6 and TGF-?1 were measured by ELISA.

Result: There was no significant difference between the decrease of FSS (p = 0.300) and VAS-F score (p = 0.085) in curcuma Vs placebo groups, respectively. The decrease of IL-6 (p = 0.061) and increase of TGF-?1 (p = 0.261) in curcuma Vs placebo group also did not differ significantly. There was no correlation between fatigue and IL-6 [FSS, r=0.255, p=0.117], [VAS, r=0.086, p=0.625], also between fatigue and TGF-?1 [FSS, r=0.127, p=0.441], [VAS-F, r=0.510, p=0.109].

Conclusion: The addition of Curcuma xanthorriza had no significant effect on fatigue and alteration of IL-6, as well as TGF-?1 serum. There were no correlations between fatigue, IL-6 and TGF-?1 serum.

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Author Biographies

Irene Saveria, Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia

Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia

Handono Kalim, Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia

Rheumatology and Immunology division, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar General Hospital Malang, Indonesia

Kusworini Handono, Department of Clinical Pathology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia

Department of Clinical Pathology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia

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