Hubungan antara penggunaan obat antiretroviral  berbasis evafirenz dengan prevalensi gangguan depresi pada penderita HIV di klinik penyakit tropik dan infeksi terpadu RSUP Sanglah

I Putu Oka Yudaswara Pande; I Made Susila  Utama; Anak Agung Ayu Yuli  Gayatri; Made Dewi Dian  Sukmawati; Ketut Agus  Somia; Ketut Tuti Parwati  Merati

doi:10.36216/jpd.v5i1.90

Authors

I Putu Oka Yudaswara Pande Program Studi Pendidikan Dokter Spesialis Penyakit Dalam, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
I Made Susila Utama Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Anak Agung Ayu Yuli Gayatri Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Made Dewi Dian Sukmawati Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Ketut Agus Somia Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Ketut Tuti Parwati Merati Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.36216/jpd.v5i1.90

Keywords:

Efavirenz-based ARV, depression prevalence, Beck Depression Inventory-II

Abstract

Background: Efavirenz as the first-line ARV most frequently used worldwide has a neuropsychiatric side effect that is still debated. Early identification of depressive symptoms determines adherence to treatment.

Objective: To determine the prevalence of depressive disorders in a population of HIV patients using efavirenz-based ARVs.

Methods: This study used a cross-sectional observational research design with a consecutive sampling method that was conducted at the Sanglah Hospital's Integrated Tropical Disease and Infectious Disease Clinic during May to June 2019. Measurement of depression used the Beck Depression Inventory-II questionnaire. Data analysis used SPSS version 21 with chi square test.

Result: The sample size was 90 people, the majority were men (58.9%) with a mean age of 36 ± 7.23 years and a long period of suffering from HIV 5 ± 3.82 years. The population of respondents who received efavirenz-based ARVs was 65.6% with a depression prevalence of 37.3%. The results of the chi-square test analysis showed that there was no significant relationship between the use of Efavirenz-based ARVs and the prevalence of depressive disorders (p = 0.86).

Conclusion: More than a third of the sample population had a depressive disorder and was not associated with the use of EFV-based ARVs.

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Author Biographies

I Putu Oka Yudaswara Pande, Program Studi Pendidikan Dokter Spesialis Penyakit Dalam, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Program Studi Pendidikan Dokter Spesialis Penyakit Dalam, Fakultas Kedokteran Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
I Made Susila Utama , Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Anak Agung Ayu Yuli Gayatri , Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Made Dewi Dian Sukmawati , Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Ketut Agus Somia , Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia
Ketut Tuti Parwati Merati , Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

Departemen/KSM Penyakit Dalam, Fakultas Kedokteran, Universitas Udayana/RSUP Sanglah, Denpasar, Bali, Indonesia

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